Acid Sphingomyelinase (ASM), Polyclonal Antibody

SMPD1; NPD; SMase; aSMase; Sphingomyelin Phosphodiesterase 1, Acid Lysosomal; Simply Sphingomyelinase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-ASM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

69,624 Da

sphingomyelin phosphodiesterase 1

sphingomyelin phosphodiesterase

Sphingomyelin phosphodiesterase

ASM; aSMase  [Similar Products]

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

SMPD1: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. Monomer. Belongs to the acid sphingomyelinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.12; Lipid Metabolism - sphingolipid; Phosphodiesterase

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: endosome; extracellular space; lysosomal lumen; lysosome; plasma membrane

Molecular Function: protein binding; sphingomyelin phosphodiesterase activity; zinc ion binding

Biological Process: ceramide biosynthetic process; glycosphingolipid metabolic process; negative regulation of MAP kinase activity; nervous system development; positive regulation of protein amino acid dephosphorylation; signal transduction; sphingomyelin catabolic process; sphingomyelin metabolic process

Disease: Niemann-pick Disease, Type A; Niemann-pick Disease, Type B

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