WISP3, Polyclonal Antibody

WNT1-inducible-signaling pathway protein 3; WISP-3; CCN family member 6; WISP3; CCN6; UNQ462/PRO790/PRO956

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-WISP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:5000
IHC: 1:20-1:200

Western Blot
Positive WB detected in: HepG2 whole cell lysate,Rat brain tissue,Rat heart tissue,Mouse heart tissue,Mouse brain tissue,Mouse kidney tissue
All lanes: WISP3 antibody at 3.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40,42 KDa
Observed band size: 40 KDa

Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7052501 at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using MBS7052501 at dilution of 1:100

41,402 Da

WNT1 inducible signaling pathway protein 3

WNT1-inducible-signaling pathway protein 3

WNT1-inducible-signaling pathway protein 3

CCN6; WISP-3  [Similar Products]

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WISP3: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC). PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding

Biological Process: cell adhesion; cell-cell signaling; signal transduction

Disease: Arthropathy, Progressive Pseudorheumatoid, Of Childhood

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