Full Product Name
WISP3 Antibody, Biotin conjugated
Product Synonym Names
WNT1-inducible-signaling pathway protein 3; WISP-3; CCN family member 6; WISP3; CCN6; UNQ462/PRO790/PRO956
Product Gene Name
anti-WISP3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95389
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human WNT1-inducible-signaling pathway protein 3 protein (201-372AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-WISP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-WISP3 antibody
Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.
Applications Tested/Suitable for anti-WISP3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for WISP3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003871.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003880.3
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UniProt Primary Accession #
O95389
[Other Products]
UniProt Secondary Accession #
Q3KR29; Q5H8W4; Q6UXH6[Other Products]
UniProt Related Accession #
O95389[Other Products]
Molecular Weight
41,402 Da
NCBI Official Full Name
WNT1-inducible-signaling pathway protein 3 isoform 1
NCBI Official Synonym Full Names
WNT1 inducible signaling pathway protein 3
NCBI Official Symbol
WISP3 [Similar Products]
NCBI Official Synonym Symbols
PPD; CCN6; LIBC; PPAC; WISP-3
[Similar Products]
NCBI Protein Information
WNT1-inducible-signaling pathway protein 3
UniProt Protein Name
WNT1-inducible-signaling pathway protein 3
UniProt Synonym Protein Names
CCN family member 6
Protein Family
WNT1-inducible-signaling pathway protein
UniProt Gene Name
WISP3 [Similar Products]
UniProt Synonym Gene Names
CCN6; WISP-3 [Similar Products]
NCBI Summary for WISP3
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for WISP3
WISP3: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC). PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: proteinaceous extracellular matrix
Molecular Function: heparin binding; integrin binding
Biological Process: cell adhesion; cell-cell signaling; signal transduction
Disease: Arthropathy, Progressive Pseudorheumatoid, Of Childhood
Research Articles on WISP3
1. Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer.
Precautions
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Disclaimer
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