Product Name
IFN-gamma R1/CD119 (IFNGR1), Protein
Full Product Name
IFNgamma R1/CD119(Fc fusion)
Product Synonym Names
CD119; Interferon gamma receptor 1; IFNGR1; IFN-gamma receptor 1; IFN-gamma-R1; CD119 antigen; IFN gamma receptor 1; IFNGR; immune interferon receptor 1; interferon gamma receptor 1; interferon-gamma receptor alpha chain
Product Gene Name
IFNGR1 protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15260
Purity/Purification
Greater than 95% as determined by reducing SDS-PAGE.
Expression System
Human Cells
Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 mug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Endotoxin
Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Preparation and Storage
Lyophilized protein should be stored at <-20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.
Aliquots of reconstituted samples are stable at <-20 degree C for 3 months.
Other Notes
Small volumes of IFNGR1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IFNGR1 protein
Background: The tetrameric receptor complex for IFN gamma consists of two subunits, IFNGR1 (IFN gamma Ralpha) and IFNGR2 (IFN gamma Rbeta), through which the dimeric IFN-gamma exerts its
biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFN gamma binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 , a signal transducer and activator of transcription 1 (STAT1) . The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).
Description: Recombinant Mouse Interferon gamma Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala26-Asp253 is expressed with a Fc tag at the C-terminus.
NCBI/Uniprot data below describe general gene information for IFNGR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000407.1
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NCBI GenBank Nucleotide #
NM_000416.2
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UniProt Primary Accession #
P15260
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UniProt Secondary Accession #
Q53Y96; B4DFT7; E1P587[Other Products]
UniProt Related Accession #
P15260[Other Products]
Molecular Weight
21,542 Da[Similar Products]
NCBI Official Full Name
interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
IFNGR1 [Similar Products]
NCBI Official Synonym Symbols
CD119; IFNGR; IMD27A; IMD27B
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NCBI Protein Information
interferon gamma receptor 1
UniProt Protein Name
Interferon gamma receptor 1
UniProt Synonym Protein Names
CDw119; Interferon gamma receptor alpha-chain
Protein Family
Interferon gamma receptor
UniProt Gene Name
IFNGR1 [Similar Products]
UniProt Synonym Gene Names
IFN-gamma-R-alpha [Similar Products]
NCBI Summary for IFNGR1
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNGR1
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550).
Research Articles on IFNGR1
1. All known mutations, as well as 287 other variations, have been deposited in the online IFNGR1 variation database . In this article, we review the function of IFN-gammaR1 and molecular genetics of human IFNGR1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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