Product Name
LTAP (VANGL2), Polyclonal Antibody
Full Product Name
Anti-LTAP Antibody
Product Synonym Names
KIAA1215; STB1; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Product Gene Name
anti-VANGL2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9ULK5
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of LTAP protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human LTAP
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-VANGL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-VANGL2 antibody
Rabbit polyclonal antibody to LTAP
Applications Tested/Suitable for anti-VANGL2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-VANGL2 antibody
Western Blot: 1/500 - 1/2000, Immunohistochemistry: 1/50 - 1/100
Western Blot (WB) of anti-VANGL2 antibody
Western blot analysis of LTAP expression in Hela (A), A549 (B), mouse brain (C) whole cell lysates.
Immunohistochemistry (IHC) of anti-VANGL2 antibody
Immunohistochemical analysis of LTAP staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
NCBI/Uniprot data below describe general gene information for VANGL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065068.1
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NCBI GenBank Nucleotide #
NM_020335.2
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UniProt Primary Accession #
Q9ULK5
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UniProt Secondary Accession #
Q5T212; D3DVE9[Other Products]
UniProt Related Accession #
Q9ULK5[Other Products]
Molecular Weight
59,714 Da
NCBI Official Full Name
vang-like protein 2
NCBI Official Synonym Full Names
VANGL planar cell polarity protein 2
NCBI Official Symbol
VANGL2 [Similar Products]
NCBI Official Synonym Symbols
LPP1; LTAP; STB1; STBM; STBM1
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NCBI Protein Information
vang-like protein 2
UniProt Protein Name
Vang-like protein 2
UniProt Synonym Protein Names
Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family
Vang-like protein
UniProt Gene Name
VANGL2 [Similar Products]
UniProt Synonym Gene Names
KIAA1215; STB1 [Similar Products]
UniProt Entry Name
VANG2_HUMAN
NCBI Summary for VANGL2
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
UniProt Comments for VANGL2
VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.
Protein type: Adaptor/scaffold; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q22-q23
Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane
Molecular Function: protein binding
Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis
Disease: Neural Tube Defects
Research Articles on VANGL2
1. VANGL2 is overexpressed in basal breast cancers. It is involved in the proliferative signal cascade of the VANGL2-SQSTM1-JNK pathway.
Precautions
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Disclaimer
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