Myotubularin Related Protein 2 (MTMR2), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of MTMR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9365860 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Myotubularin Related Protein 2 (MTMR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MTMR2. The ELISA analytical biochemical technique of the MBS9365860 kit is based on MTMR2 antibody-MTMR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MTMR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MTMR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

65,959 Da

myotubularin related protein 2

myotubularin-related protein 2

Myotubularin-related protein 2

KIAA1073  [Similar Products]

MTMR2_HUMAN

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Protein type: Cofactor and Vitamin Metabolism - thiamine; Phosphatase, lipid; Carbohydrate Metabolism - fructose and mannose; EC 3.1.3.95; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.64

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: axon; cytoplasm; cytosol; dendrite; dendritic spine; early endosome membrane; nucleus; synaptic vesicle; vacuolar membrane

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; protein homodimerization activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity

Biological Process: inositol phosphate dephosphorylation; myelin formation; negative regulation of endocytosis; negative regulation of myelination; negative regulation of receptor internalization; neuron development; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phospholipid metabolic process; protein amino acid dephosphorylation; protein tetramerization

Disease: Charcot-marie-tooth Disease, Type 4b1

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