1-acyl-sn-glycerol-3-phosphate acyltransferase beta, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of AGPAT2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2608001 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AGPAT2. The ELISA analytical biochemical technique of the MBS2608001 kit is based on AGPAT2 antibody-AGPAT2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AGPAT2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AGPAT2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

27,279 Da

1-acylglycerol-3-phosphate O-acyltransferase 2

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1-AGP acyltransferase 2; 1-AGPAT 2; LPAAT-beta  [Similar Products]

PLCB_HUMAN

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

AGPAT2: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1); also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; Lipid Metabolism - glycerolipid; Membrane protein, multi-pass; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 2.3.1.51

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane

Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: CDP-diacylglycerol biosynthetic process; cellular lipid metabolic process; epidermis development; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; phospholipid metabolic process; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of cytokine production; triacylglycerol biosynthetic process

Disease: Lipodystrophy, Congenital Generalized, Type 1

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