Product Name
DAP12, Peptide
Full Product Name
DAP12 Blocking Peptide
Product Gene Name
DAP12 peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Form/Format
50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (lot specific)
Handling
The peptide solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of DAP12 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for DAP12 peptide
Western Blot (WB)
Application Notes for DAP12 peptide
The peptide is used for blocking the antibody activity of DAP-12. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.
NCBI/Uniprot data below describe general gene information for DAP12. It may not necessarily be applicable to this product.
NCBI Accession #
AAD09438
[Other Products]
UniProt Secondary Accession #
O88603[Other Products]
UniProt Related Accession #
O54885[Other Products]
Molecular Weight
12,367 Da
NCBI Official Full Name
DAP12
NCBI Official Synonym Full Names
TYRO protein tyrosine kinase binding protein
NCBI Official Symbol
Tyrobp [Similar Products]
NCBI Official Synonym Symbols
Ly83; DAP12; KARAP
[Similar Products]
NCBI Protein Information
TYRO protein tyrosine kinase-binding protein
UniProt Protein Name
TYRO protein tyrosine kinase-binding protein
UniProt Synonym Protein Names
DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein
UniProt Gene Name
Tyrobp [Similar Products]
UniProt Synonym Gene Names
Dap12; Karap; KAR-associated protein [Similar Products]
UniProt Entry Name
TYOBP_MOUSE
UniProt Comments for DAP12
TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: cell surface; membrane; integral to membrane
Molecular Function: identical protein binding; protein binding; receptor binding
Biological Process: integrin-mediated signaling pathway; neutrophil activation during immune response; macrophage activation during immune response
Research Articles on DAP12
1. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
