DAP12, Polyclonal Antibody

Rabbit Polyclonal; TYROBP; DNAX-activation protein 12; DAP12; PLOSL; KARAP; KAR-associated protein; PLO-SL

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Recognizes mouse DAP-12. Species cross-reactivity: human, rat.

Immunoaffinity Purified

PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol

Short term: 4 degree C
Long term: -20 degree C.
Avoid freeze-thaw cycles.

Small volumes of anti-DAP12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

DAP12 is a transmembrane signaling polypeptide which contains animmunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmicdomain. the encoded protein may associate with the killer-cellinhibitory receptor (KIR) family of membrane glycoproteins and may actas an activating signal transduction element.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 5 ug/ml
WB: 0.5-4 ug/ml

Anti-DAP12 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

11,043 Da

TYRO protein tyrosine kinase binding protein

TYRO protein tyrosine kinase-binding protein

TYRO protein tyrosine kinase-binding protein

DAP12; KARAP; KAR-associated protein  [Similar Products]

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

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