Full Product Name
ACR antibody - C-terminal region
Product Gene Name
anti-ACR antibody
[Similar Products]
Antibody/Peptide Pairs
ACR peptide (MBS3240748) is used for blocking the activity of ACR antibody (MBS3215846)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: GKIDTCQGDS GGPLMCKDSK ESAYVVVGIT SWGVGCARAK RPGIYTATWP
3D Structure
ModBase 3D Structure for P10323
Species Reactivity
Cow, Horse, Human, Sheep
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 79%; Horse: 79%; Human: 100%; Sheep: 79%
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ACR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACR antibody
This is a rabbit polyclonal antibody against ACR. It was validated on Western Blot
Target Description: Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
Product Categories/Family for anti-ACR antibody
Polyclonal; Various;
Applications Tested/Suitable for anti-ACR antibody
Western Blot (WB)
Western Blot (WB) of anti-ACR antibody
WB Suggested Anti-ACR Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Lung
NCBI/Uniprot data below describe general gene information for ACR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001088
[Other Products]
NCBI GenBank Nucleotide #
NM_001097
[Other Products]
UniProt Primary Accession #
P10323
[Other Products]
UniProt Related Accession #
P10323[Other Products]
NCBI Official Full Name
acrosin
NCBI Official Synonym Full Names
acrosin
NCBI Official Symbol
ACR [Similar Products]
NCBI Protein Information
acrosin
UniProt Protein Name
Acrosin
UniProt Gene Name
ACR [Similar Products]
UniProt Synonym Gene Names
ACRS [Similar Products]
UniProt Entry Name
ACRO_HUMAN
NCBI Summary for ACR
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
UniProt Comments for ACR
ACR: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family.
Protein type: Protease; EC 3.4.21.10
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: protein complex; extracellular region; Golgi-associated vesicle; nucleus; acrosomal matrix
Molecular Function: mannose binding; protein binding; copper ion binding; amidase activity; DNA binding; zinc ion binding; serine-type endopeptidase activity; drug binding; fucose binding
Biological Process: response to steroid hormone stimulus; binding of sperm to zona pellucida; single fertilization; acrosome reaction; adenylate cyclase activation; penetration of zona pellucida; acrosome matrix dispersal; multicellular organism reproduction
Research Articles on ACR
1. Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
