IL1RAPL1, Polyclonal Antibody

IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-IL1RAPL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:50

79,969 Da

interleukin 1 receptor accessory protein-like 1

interleukin-1 receptor accessory protein-like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1; interleukin 1 receptor-8; mental retardation, X-linked 10; oligophrenin-4; three immunoglobulin domain-containing IL-1 receptor-related 2

Interleukin-1 receptor accessory protein-like 1

OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2  [Similar Products]

IRPL1_HUMAN

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: Xp22.1-p21.3

Cellular Component: postsynaptic membrane; cell surface; axon; dendrite; cytoplasm; integral to membrane; plasma membrane

Molecular Function: voltage-gated calcium channel activity; protein binding; interleukin-1 binding; receptor binding

Biological Process: neuron differentiation; heterophilic cell adhesion; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction

Disease: Mental Retardation, X-linked 21

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