Interleukin 1 Receptor Accessory Protein Like Protein 1 (IL1RAPL1), Antibody Pa

IL1R8; IL1RAPL; MRX21; MRX34; OPHN4; TIGIRR-2; Mental Retardation,X-Linked 34; Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2

For Research Use Only. Not for use in diagnostic procedures.

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Small volumes of IL1RAPL1 antibody pair kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cytokine

ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex

79,969 Da

interleukin 1 receptor accessory protein like 1

interleukin-1 receptor accessory protein-like 1

Interleukin-1 receptor accessory protein-like 1

OPHN4; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; TIGIRR-2  [Similar Products]

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:12783849). May activate the MAP kinase JNK (PubMed:15123616). Plays a role in neurite outgrowth (). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD ().

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