Full Product Name
Human MCFD2 Polyclonal Antibody
Product Synonym Names
SDNSF; Neural stem cell-derived neuronal survival protein
Product Gene Name
anti-MCFD2 antibody
[Similar Products]
Matching Pairs
Antibody: MCFD2 (MBS2897307)
Antigen: Multiple coagulation factor deficiency protein 2 (MBS2889236)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NI22
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human MCFD2 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-MCFD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MCFD2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for MCFD2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001164977.1
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NCBI GenBank Nucleotide #
NP_001164977.1
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UniProt Primary Accession #
Q8NI22
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UniProt Related Accession #
Q8NI22[Other Products]
NCBI Official Full Name
multiple coagulation factor deficiency protein 2 isoform A
NCBI Official Synonym Full Names
multiple coagulation factor deficiency 2
NCBI Official Symbol
MCFD2 [Similar Products]
NCBI Official Synonym Symbols
F5F8D; SDNSF; F5F8D2; LMAN1IP
[Similar Products]
NCBI Protein Information
multiple coagulation factor deficiency protein 2
UniProt Protein Name
Multiple coagulation factor deficiency protein 2
UniProt Synonym Protein Names
Neural stem cell-derived neuronal survival protein
Protein Family
Multiple coagulation factor deficiency protein
UniProt Gene Name
MCFD2 [Similar Products]
UniProt Synonym Gene Names
SDNSF [Similar Products]
UniProt Entry Name
MCFD2_HUMAN
NCBI Summary for MCFD2
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in ***** central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2016]
UniProt Comments for MCFD2
MCFD2: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: Golgi apparatus; endoplasmic reticulum; ER-Golgi intermediate compartment
Molecular Function: calcium ion binding
Biological Process: vesicle-mediated transport; protein transport; cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Disease: Factor V And Factor Viii, Combined Deficiency Of, 2
Research Articles on MCFD2
1. that Multiple coagulation factor deficiency protein 2 promotes cancer metastasis by regulating lectin mannose binding 1 and level of galactoside-binding soluble 3 binding protein expression levels
Precautions
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Disclaimer
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