Interleukin-1 receptor accessory protein-like 1 (Il1rapl1), Recombinant Protein

Interleukin-1 receptor accessory protein-like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Il1rapl1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

79,771 Da

interleukin 1 receptor accessory protein-like 1

interleukin-1 receptor accessory protein-like 1; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1

Interleukin-1 receptor accessory protein-like 1

IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1  [Similar Products]

IRPL1_RAT

member of the interleukin 1 receptor family; mutation of human homolog may be involved is associated with X-linked mental retardation [RGD, Feb 2006]

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: cell surface; axon; cytoplasm; dendrite; integral to membrane; plasma membrane

Molecular Function: voltage-gated calcium channel activity; interleukin-1 binding; receptor binding

Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction

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