Full Product Name
CHRM3 antibody
Product Synonym Names
Polyclonal CHRM3; Anti-CHRM3; m3 muscarinic receptor; CHRM -3; muscarinic acetylcholine receptor m3; chrm3; CHRM3; muscarinic cholinergic m3 receptor; muscarinic receptor m3; CHRM 3; m3 muscarinic acetylcholine receptor; muscarinic m3 receptor
Product Gene Name
anti-CHRM3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20309
Purity/Purification
CHRM3 antibody was purified by affinity chromatography.
Form/Format
Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
Concentration
1.0 mg/ml (lot specific)
Biological Significance
The muscarinic acetylcholine receptor M3, also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor. It is encoded by the human gene CHRM3. The M3 muscarinic receptors are located at many places in the body, e.g., smooth muscles, the endocrine glands, the exocrine glands, as well as the lungs. They are also found in the CNS, where they induce emesis. In general, they cause smooth muscle contraction and increased glandular secretions.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
CHRM3 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CHRM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHRM3 antibody
Rabbit polyclonal CHRM3 antibody
Product Categories/Family for anti-CHRM3 antibody
Signal Transduction
Applications Tested/Suitable for anti-CHRM3 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CHRM3 antibody
IHC-P: 10 ug/ml
NCBI/Uniprot data below describe general gene information for CHRM3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000731.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000740.2
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UniProt Primary Accession #
P20309
[Other Products]
UniProt Secondary Accession #
Q0VAJ8; Q4QRI3; Q5VXY2; Q9HB60[Other Products]
UniProt Related Accession #
P20309[Other Products]
Molecular Weight
66,128 Da
NCBI Official Full Name
muscarinic acetylcholine receptor M3
NCBI Official Synonym Full Names
cholinergic receptor, muscarinic 3
NCBI Official Symbol
CHRM3 [Similar Products]
NCBI Official Synonym Symbols
HM3; EGBRS
[Similar Products]
NCBI Protein Information
muscarinic acetylcholine receptor M3
UniProt Protein Name
Muscarinic acetylcholine receptor M3
Protein Family
Muscarinic acetylcholine receptor
UniProt Gene Name
CHRM3 [Similar Products]
UniProt Entry Name
ACM3_HUMAN
NCBI Summary for CHRM3
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
UniProt Comments for CHRM3
mAChR M3: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: asymmetric synapse; postsynaptic membrane; integral to plasma membrane; basolateral plasma membrane; dendrite; plasma membrane; nerve terminal; cell junction
Molecular Function: protein binding; receptor activity; drug binding; acetylcholine binding; phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; nervous system development; smooth muscle contraction; acetylcholine receptor signaling, muscarinic pathway; regulation of vascular smooth muscle contraction; energy reserve metabolic process; protein modification process; positive regulation of smooth muscle contraction; signal transduction; regulation of insulin secretion; saliva secretion
Disease: Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
Research Articles on CHRM3
1. M3R preserves the endothelial barrier function through a mechanism potentially maintaining PTP1B activity, keeping the adherens junction proteins (AJPs) dephosphorylation.
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