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Multiple coagulation factor deficiency protein 2 (MCFD2), Recombinant Protein

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产品名称: Multiple coagulation factor deficiency protein 2 (MCFD2), Recombinant Protein
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简单介绍

Multiple coagulation factor deficiency protein 2 (MCFD2), Recombinant Protein


Multiple coagulation factor deficiency protein 2 (MCFD2), Recombinant Protein  的详细介绍
Product Name

Multiple coagulation factor deficiency protein 2 (MCFD2), Recombinant Protein

Full Product Name

Recombinant Human Multiple coagulation factor deficiency protein 2 (MCFD2)

Product Gene Name

MCFD2 recombinant protein

[Similar Products]
Product Synonym Gene Name
MCFD2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence Positions
27-146aa, Full Length of Mature Protein
Sequence
EEPAASFSQP GSMGLDKNTV HDQEHIMEHL EGVINKPEAE MSPQELQLHY FKMHDYDGNN LLDGLELSTA ITHVHKEEGS EQAPLMSEDE LINIIDGVLR DDDKNNDGYI DYAEFAKSLQ
OMIM
607788
3D Structure
ModBase 3D Structure for Q8NI22
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MCFD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MCFD2. It may not necessarily be applicable to this product.
NCBI GI #
284005451
NCBI GeneID
90411
NCBI Accession #
NP_001164977.1 [Other Products]
NCBI GenBank Nucleotide #
NM_001171506.2 [Other Products]
UniProt Primary Accession #
Q8NI22 [Other Products]
UniProt Secondary Accession #
Q53SS3; Q68D61; Q8N3M5; A8K7W2; D6W5A9; E9PD95[Other Products]
UniProt Related Accession #
Q8NI22[Other Products]
Molecular Weight
14,431 Da
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NCBI Official Full Name
multiple coagulation factor deficiency protein 2 isoform A
NCBI Official Synonym Full Names
multiple coagulation factor deficiency 2
NCBI Official Symbol
MCFD2  [Similar Products]
NCBI Official Synonym Symbols
F5F8D; SDNSF; F5F8D2; LMAN1IP
  [Similar Products]
NCBI Protein Information
multiple coagulation factor deficiency protein 2
UniProt Protein Name
Multiple coagulation factor deficiency protein 2
UniProt Synonym Protein Names
Neural stem cell-derived neuronal survival protein
Protein Family
Multiple coagulation factor deficiency protein
UniProt Gene Name
MCFD2  [Similar Products]
UniProt Synonym Gene Names
SDNSF  [Similar Products]
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NCBI Summary for MCFD2
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in ***** central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2016]
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UniProt Comments for MCFD2
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
Research Articles on MCFD2
1. A novel missense mutation, namely Asp81Ala in exon 3 of MCFD2 gene, is firstly reported and described as a cause of combined FV and FVIII deficiency in a Chinese family.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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