Full Product Name
PRL Antibody (Center)
Product Synonym Names
Prolactin; PRL; PRL
Product Gene Name
anti-PRL antibody
[Similar Products]
Antibody/Peptide Pairs
PRL peptide (MBS9221970) is used for blocking the activity of PRL antibody (MBS9210284)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
48-76
3D Structure
ModBase 3D Structure for P01236
Specificity
This PRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-76 amino acids from the Central region of human PRL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PRL antibody
PRL prolactin acts primarily on the mammary gland by promoting lactation.
Product Categories/Family for anti-PRL antibody
Cancer; Signal Transduction
Applications Tested/Suitable for anti-PRL antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PRL antibody
WB~~1:1000
Western Blot (WB) of anti-PRL antibody
PRL Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PRL antibody detected the PRL protein (arrow).
NCBI/Uniprot data below describe general gene information for PRL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000939.1
[Other Products]
NCBI Related Accession #
HumanNP_001157030.1[Other Products]
NCBI GenBank Nucleotide #
NM_000948.5
[Other Products]
UniProt Primary Accession #
P01236
[Other Products]
UniProt Secondary Accession #
Q15199; Q92996[Other Products]
UniProt Related Accession #
P01236[Other Products]
NCBI Official Full Name
prolactin
NCBI Official Synonym Full Names
prolactin
NCBI Official Symbol
PRL [Similar Products]
NCBI Protein Information
prolactin
UniProt Protein Name
Prolactin
UniProt Gene Name
PRL [Similar Products]
UniProt Synonym Gene Names
PRL [Similar Products]
UniProt Entry Name
PRL_HUMAN
NCBI Summary for PRL
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
UniProt Comments for PRL
prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component: extracellular region
Molecular Function: protein binding; prolactin receptor binding; hormone activity
Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; positive regulation of JAK-STAT cascade; regulation of multicellular organism growth; female pregnancy
Product References and Citations for anti-PRL antibody
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Strauss, J.S., et al. Psychoneuroendocrinology 35(9):1422-1428(2010)
Gordon, I., et al. Horm Behav 58(3):513-518(2010)
Voorhees, J.L., et al. J. Biol. Chem. 285(26):20022-20030(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Research Articles on PRL
1. The prevalence and predictors of hyperprolactinemia in 178 patients with liver cirrhosis of different etio-logies, were investigated.
Precautions
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Disclaimer
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