Product Name
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (Abhd5), Recombinant Protein
Popular Item
Full Product Name
Recombinant Mouse 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (Abhd5)
Product Gene Name
Abhd5 recombinant protein
[Similar Products]
Product Synonym Gene Name
Abhd5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-351aa, full length protein
Sequence
MKAMAAEEEV DSADAGGGSG WLTGWLPTWC PTSTSHLKEA EEKMLKCVPC TYKKEPVRIS NGNRIWTLMF SHNISSKTPL VLLHGFGGGL GLWALNFEDL STDRPVYAFD LLGFGRSSRP RFDSDAEEVE NQFVESIEEW RCALRLDKMI LLGHNLGGFL AAAYSLKYPS RVSHLILVEP WGFPERPDLA DQERPIPVWI RALGAALTPF NPLAGLRIAG PFGLSLVQRL RPDFKRKYSS MFEDDTVTEY IYHCNVQTPS GETAFKNMTI PYGWAKRPML QRIGGLHPDI PVSVIFGARS CIDGNSGTSI QSLRPKSYVK TIAILGAGHY VYADQPEEFN QKVKEICHTV D
3D Structure
ModBase 3D Structure for Q9DBL9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Abhd5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Abhd5 recombinant protein
This protein belongs to a large family of proteins defined by an alpha
beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase
lipase
thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.
NCBI/Uniprot data below describe general gene information for Abhd5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_080455.1
[Other Products]
NCBI GenBank Nucleotide #
NM_026179.2
[Other Products]
UniProt Primary Accession #
Q9DBL9
[Other Products]
UniProt Secondary Accession #
Q9CTY3[Other Products]
UniProt Related Accession #
Q9DBL9[Other Products]
Molecular Weight
21,846 Da
NCBI Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1
NCBI Official Synonym Full Names
abhydrolase domain containing 5
NCBI Official Symbol
Abhd5 [Similar Products]
NCBI Official Synonym Symbols
CDS; IECN5; NCIE2; CGI-58; 1300003D03Rik; 2010002J10Rik
[Similar Products]
NCBI Protein Information
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
UniProt Protein Name
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
UniProt Synonym Protein Names
Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58; Protein CGI-58
Protein Family
1-acylglycerol-3-phosphate O-acyltransferase
UniProt Gene Name
Abhd5 [Similar Products]
UniProt Synonym Gene Names
Protein CGI-58 [Similar Products]
UniProt Comments for Abhd5
Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:16679289). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:16679289). Regulates lipid droplet fusion (PubMed:26083785).
Research Articles on Abhd5
1. Prebinding CGI-58 with PI(3)P or PI(5)P did not alter its coactivation of ATGL in vitro. In summary, purified recombinant CGI-58 that is functional as an ATGL coactivator lacks LPAAT activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.