TRAPPC9, Polyclonal Antibody

Trafficking protein particle complex subunit 9; NIK- and IKBKB-binding protein; Tularik gene 1 protein; TRAPPC9; KIAA1882; NIBP; T1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-TRAPPC9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Immunohistochemistry of paraffin-embedded human heart tissue using MBS7050859 at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using MBS7050859 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

127,607 Da

trafficking protein particle complex 9

trafficking protein particle complex subunit 9

Trafficking protein particle complex subunit 9

KIAA1882; NIBP  [Similar Products]

TPPC9_HUMAN

This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive mental retardation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

NIBP: Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Defects in TRAPPC9 are the cause of mental retardation autosomal recessive type 13 (MRT13). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals. Belongs to the NIBP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Activator

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cytosol; trans-Golgi network

Biological Process: cerebral cortex development; COPII coating of Golgi vesicle

Disease: Mental Retardation, Autosomal Recessive 13

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