Product Name
Trifunctional enzyme subunit alpha, mitochondrial (Hadha), Recombinant Protein
Popular Item
Full Product Name
Recombinant Mouse Trifunctional enzyme subunit alpha, mitochondrial (Hadha), partial
Product Gene Name
Hadha recombinant protein
[Similar Products]
Product Synonym Gene Name
Hadha[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
348-763aa; Partial
Sequence
LCKKNKFGAP QKNVQQLAIL GAGLMGAGIA QVSVDKGLKT LLKDTTVTGL GRGQQQVFKG LNDKVKKKAL TSFERDSIFS NLIGQLDYKG FEKADMVIEA VFEDLGVKHK VLKEVESVTP EHCIFASNTS ALPINQIAAV SKRPEKVIGM HYFSPVDKMQ LLEIITTDKT SKDTTASAVA VGLRQGKVII VVKDGPGFYT TRCLAPMMSE VMRILQEGVD PKKLDALTTG FGFPVGAATL ADEVGVDVAQ HVAEDLGKAF GERFGGGSVE LLKQMVSKGF LGRKSGKGFY IYQEGSKNKS LNSEMDNILA NLRLPAKPEV SSDEDVQYRV ITRFVNEAVL CLQEGILATP AEGDIGAVFG LGFPPCLGGP FRFVDLYGAQ KVVDRLRKYE SAYGTQFTPC QLLLDHANNS SKKFYQ
3D Structure
ModBase 3D Structure for Q8BMS1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hadha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Hadha recombinant protein
This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation.
NCBI/Uniprot data below describe general gene information for Hadha. It may not necessarily be applicable to this product.
NCBI Accession #
NP_849209.1
[Other Products]
NCBI GenBank Nucleotide #
NM_178878.2
[Other Products]
UniProt Primary Accession #
Q8BMS1
[Other Products]
UniProt Secondary Accession #
Q3TCY3; Q5U5Y5; Q8QZU4[Other Products]
UniProt Related Accession #
Q8BMS1[Other Products]
Molecular Weight
82,670 Da
NCBI Official Full Name
trifunctional enzyme subunit alpha, mitochondrial
NCBI Official Synonym Full Names
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
NCBI Official Symbol
Hadha [Similar Products]
NCBI Official Synonym Symbols
Mtpa; C77020
[Similar Products]
NCBI Protein Information
trifunctional enzyme subunit alpha, mitochondrial
UniProt Protein Name
Trifunctional enzyme subunit alpha, mitochondrial
UniProt Synonym Protein Names
TP-alphaIncluding the following 2 domains:Long-chain enoyl-CoA hydratase (EC:4.2.1.17)Long chain 3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.211)
Protein Family
Trifunctional enzyme
UniProt Gene Name
Hadha [Similar Products]
UniProt Comments for Hadha
Bifunctional subunit.
Research Articles on Hadha
1. These findings suggested that palmitic acid-induced autophagy supports the survival of IECs. Taken together, these results suggested that HADHA is involved in long-chain fatty acid-induced autophagy in IECs, thus providing new insights into the pathology of IBD and revealing novel therapeutic targets of IBD.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
