Product Name
Connexin 26 (GJB2), Blocking Peptide
Full Product Name
Connexin 26 Blocking Peptide
Product Synonym Names
Gap junction beta-2 protein; Connexin-26; Cx26
Product Gene Name
GJB2 blocking peptide
[Similar Products]
Connexin 26 peptide (MBS823398) is used for blocking the activity of Connexin 26 antibody (MBS821364)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29033
Species Reactivity
Human, Dog, Monkey
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of GJB2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GJB2 blocking peptide
The peptide is used to block Anti-Connexin 26 Antibody reactivity.
Applications Tested/Suitable for GJB2 blocking peptide
Blocking (BL)
Application Notes for GJB2 blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for GJB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003995.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004004.5
[Other Products]
UniProt Primary Accession #
P29033
[Other Products]
UniProt Secondary Accession #
Q508A5; Q508A6; Q5YLL0; Q5YLL1; Q5YLL4; Q6IPV5; Q86U88; Q96AK0; Q9H536; Q9NNY4[Other Products]
UniProt Related Accession #
P29033[Other Products]
Molecular Weight
26,215 Da
NCBI Official Full Name
gap junction beta-2 protein
NCBI Official Synonym Full Names
gap junction protein, beta 2, 26kDa
NCBI Official Symbol
GJB2 [Similar Products]
NCBI Official Synonym Symbols
HID; KID; PPK; CX26; DFNA3; DFNB1; NSRD1; DFNA3A; DFNB1A
[Similar Products]
NCBI Protein Information
gap junction beta-2 protein; connexin 26; gap junction protein beta 2
UniProt Protein Name
Gap junction beta-2 protein
UniProt Synonym Protein Names
Connexin-26; Cx26
Protein Family
Gap junction beta-2 protein
UniProt Gene Name
GJB2 [Similar Products]
UniProt Synonym Gene Names
Cx26 [Similar Products]
UniProt Entry Name
CXB2_HUMAN
NCBI Summary for GJB2
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
UniProt Comments for GJB2
GJB2: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJB2 are the cause of deafness autosomal recessive type 1A (DFNB1A). DFNB1A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in GJB2 are the cause of deafness autosomal dominant type 3A (DFNA3A). Defects in GJB2 are a cause of Vohwinkel syndrome (VS). VS is an autosomal dominant disease characterized by hyperkeratosis, constriction on finger and toes and congenital deafness. Defects in GJB2 are a cause of palmoplantar keratoderma with deafness (PPKDFN). PPKDFN is an autosomal dominant disorder characterized by the association of palmoplantar hyperkeratosis with progressive, bilateral, high-frequency, sensorineural deafness. Defects in GJB2 are a cause of keratitis-ichthyosis- deafness syndrome (KID syndrome); an autosomal dominant form of ectodermal dysplasia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. KID syndrome is characterized by the association of hyperkeratotic skin lesions with vascularizing keratitis and profound sensorineural hearing loss. Clinical features include deafness, ichthyosis, photobia, absent or decreased eyebrows, sparse or absent scalp hair, decreased sweating and dysplastic finger and toenails. Defects in GJB2 are the cause of Bart-Pumphrey syndrome (BPS). BPS is an autosomal dominant disorder characterized by sensorineural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, It shows considerable phenotypic variability. Defects in GJB2 are the cause of ichthyosis hystrix-like with deafness syndrome (HID syndrome). HID syndrome is an autosomal-dominant inherited keratinizing disorder characterized by sensorineural deafness and spiky hyperkeratosis affecting the entire skin. HID syndrome is considered to differ from the similar KID syndrome in the extent and time of occurrence of skin symptoms and the severity of the associated keratitis. Belongs to the connexin family. Beta-type (group I) subfamily.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q11-q12
Cellular Component: connexon complex; plasma membrane; integral to membrane; ER-Golgi intermediate compartment; lateral plasma membrane
Molecular Function: gap junction channel activity
Biological Process: sensory perception of sound; gap junction assembly; cell-cell signaling; transport; male genitalia development; decidualization; response to progesterone stimulus; transmembrane transport; response to estradiol stimulus
Disease: Deafness, Autosomal Recessive 1a; Ichthyosis, Hystrix-like, With Deafness; Deafness, X-linked 2; Deafness, Congenital, With Keratopachydermia And Constrictions Of Fingers And Toes; Keratitis-ichthyosis-deafness Syndrome, Autosomal Dominant; Knuckle Pads, Leukonychia, And Sensorineural Deafness; Deafness, Autosomal Dominant 3a; Keratoderma, Palmoplantar, With Deafness
Research Articles on GJB2
1. GJB2 mutation is common cause for developing nonsyndromic sensorineural hearing loss.
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