SGLT1, Positive Control

D22S675; High affinity sodium glucose cotransporter 1; Human Na+/glucose cotransporter 1; NAGT; SGLT 1; SLC5A1; Sodium glucose cotransporter 1; Solute carrier family 5 member 1 antibody

For Research Use Only. Not for use in diagnostic procedures.

Western Blot Positive Control in ready to use SDS-sample buffer

Store at -20°C for long term storage

Small volumes of SGLT1 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot Positive Control Sodum/glucose cotransporter 1
Sodium-glucose linked transporters (SGL T) are a family of glucose tranporters that contribute to renal glucose reabsorption. The two most common members of SGL T family are members of the SLC5A gene family: SGL T1 and SGL T2. There are five other members in the human protein family SLC5A, which may also be sodium-glucose transporters (1). SGL Ts utilize secondary active transport to transport glucose along kidney proximal tubules by sodium ion cotransport with a sodium ion to glucose coupling ration of 2:1. A Na+/K+ ATPase pump on the basolateral membrane of the proximal tubules cells utilizes ATP to move 3 Sodium ions outward into the blood, and 2 potassium ions into the cell. The energy from the resulting downhill sodium ion gradient is utilized by SGL Ts to transport glucose across the apical membrane. Since sodium and glucose are transported in the same direction, SGL Ts are classified as symporters. SGL Ts are mainly expressed in intestine and kidney. SGL T and GLUT antibodies have been fully characterized for cross reactivity within the SGL T and GLUT families and also with other cellular proteins. Antibodies against multiple epitopes on the same protein to facilitate studies using interspecies cross reactivity. SGL T western blot positive control (PC-SGL T) is available in read-to-use SOS-PAGE sample buffer. The SGL T positive control appears as a diffuse band of 69-72 and co-migrates with rat jejune.1 sodium-dependent glucose transporter protein on a 10% SOS-PAGE.

Western Blot (WB)

Western Blot: 1:500-1:1,000

solute carrier family 5 member 1

sodium/glucose cotransporter 1

Sodium/glucose cotransporter 1

NAGT; SGLT1; Na(+)/glucose cotransporter 1  [Similar Products]

SC5A1_HUMAN

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: apical plasma membrane; brush border membrane; integral to plasma membrane; intercellular junction; plasma membrane

Molecular Function: glucose:sodium symporter activity; protein binding

Biological Process: D-glucose absorption; glucose transport; hexose transport; sodium ion transport

Disease: Glucose/galactose Malabsorption

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