Full Product Name
SGLT1 antibody
Product Synonym Names
Polyclonal SGLT1; Anti-SGLT1; SGLT 1; Sodium Glucose Transporter-1; SGLT1; SGLT -1; SGLT-1
Product Gene Name
anti-SGLT1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13866
Species Reactivity
Pig, Avian, Dog, Cat, Rabbit, Rat, Reptilia
Purity/Purification
SGLT1 antibody was purified by affinity chromatography.
Form/Format
Supplied as a lyophilized powder containing 0.05% NaN3. Reconstitute in 100 ul of water.
Biological Significance
Sodium glucose co transporters (SGLT), are active in the reabsorption of glucose in the proximal tubules of the kidneys. In the kidney, SGLT1 is expressed in proximal tubule Sq1 segments. SGLT1/NAGT or SLC5A1/NAGT (rat/mouse 665 aa; human 664 aa, chromosome 22q13.1, ~75 kDa) is a high affinity, Na+-coupled, intestinal transporter responsible for active glucose transport across the brush border membrane.
Immunogen
SGLT1 antibody was raised in rabbit using a 19 amino acid peptide sequence of mouse/rabbit SGLT-1 as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-SGLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SGLT1 antibody
Affinity purified Rabbit polyclonal SGLT1 antibody
Product Categories/Family for anti-SGLT1 antibody
Nutrition & Metabolism; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-SGLT1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SGLT1 antibody
ELISA: 0.5-1 ug/ml
WB: 1-10 ug/ml
NCBI/Uniprot data below describe general gene information for SGLT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000334.1
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NCBI GenBank Nucleotide #
NM_000343.3
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UniProt Primary Accession #
P13866
[Other Products]
UniProt Secondary Accession #
B2R7E2; B7Z4Q9; B7ZA69[Other Products]
UniProt Related Accession #
P13866[Other Products]
Molecular Weight
60,097 Da
NCBI Official Full Name
sodium/glucose cotransporter 1 isoform 1
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Official Symbol
SLC5A1 [Similar Products]
NCBI Official Synonym Symbols
NAGT; SGLT1; D22S675
[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 1
UniProt Protein Name
Sodium/glucose cotransporter 1
UniProt Synonym Protein Names
High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
UniProt Gene Name
SLC5A1 [Similar Products]
UniProt Synonym Gene Names
NAGT; SGLT1; Na(+)/glucose cotransporter 1 [Similar Products]
UniProt Entry Name
SC5A1_HUMAN
NCBI Summary for SGLT1
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for SGLT1
SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; intercellular junction
Molecular Function: protein binding; glucose:sodium symporter activity
Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; pathogenesis; glucose transport; metanephros development; transmembrane transport; intestinal absorption
Disease: Glucose/galactose Malabsorption
Research Articles on SGLT1
1. SGLT1 or GLUT2 interact with the cytoskeleton in the intestinal epithelium during hexose absorption.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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