14-3-3, Monoclonal Antibody

14 3 3 antibody; 14 3 3 protein beta antibody; 14 3 3 protein beta/alpha antibody; 14 3 3 protein zeta antibody; 14 3 3 zeta antibody; 14-3-3 protein beta/alpha antibody; 14-3-3 protein/cytosolic phospholipase A2 antibody; GW128 antibody; HS1 antibody; KCIP 1 antibody; MGC111427 antibody; MGC126532 antibody; MGC138156 antibody; Protein 1054 antibody; Protein kinase C inhibitor protein 1 antibody; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein delta polypeptide antibody; Tyrosine 3/tryptophan 5-monooxygenase activation protein; zeta polypeptide antibody; YWHAB antibody; YWHAD antibody; YWHAZ antibody; YWHAZ antibody

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG

Mouse

Affinity Purified

Colorless liquid
100 ug (0.5 mg/ml) immunoaffinity purified mouse monoclonal antibody in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol.

0.5 mg/ml (lot specific)

Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.

Small volumes of anti-14-3-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The 14-3-3 proteins comprise a family of highly conserved acidic proteins which play a role in both signal transduction and the cell cycle by binding to and regulating several different proteins. The family of proteins is present in particularly high concentrations in mammalian brain and may be involved in the regulation of neuronal activity. The 14-3-3 proteins exist as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C.

14-3-3

Western Blot (WB)

Western Blot: 1-4 ug

28,304 Da

CG17870 gene product from transcript CG17870-RE

14-3-3 protein zeta

14-3-3; 14-3-3EZ; leo; THAP  [Similar Products]

Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development (PubMed:9159395). Acts upstream of Raf and downstream of Ras, and is essential for viability (PubMed:9159395). Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob (PubMed:10230800). Inhibits yki activity by restricting its nuclear localization (PubMed:19900439). Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes (PubMed:27015288).

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