Product Name
B-cell receptor CD22, Protein
Full Product Name
B-cell receptor CD22
Product Synonym Names
Lyb-8; Siglec2; B-lymphocyte cell adhesion molecule; Sialic acid-binding Ig-like lectin 2; T-cell surface antigen Leu-14; BL-CAM; Siglec-2; CD22
Product Gene Name
CD22 protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
722-862aa
3D Structure
ModBase 3D Structure for P35329
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of CD22 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for CD22 protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for CD22. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001036782.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001043317.2
[Other Products]
UniProt Primary Accession #
P35329
[Other Products]
UniProt Secondary Accession #
Q9JHL2; Q9JJX9; Q9JJY0; Q9JJY1; Q9R056; Q9R094; Q9WU51[Other Products]
UniProt Related Accession #
P35329[Other Products]
Molecular Weight
92,857 Da
NCBI Official Full Name
B-cell receptor CD22
NCBI Official Synonym Full Names
CD22 antigen
NCBI Official Symbol
Cd22 [Similar Products]
NCBI Official Synonym Symbols
Lyb8; Lyb-8; A530093D23
[Similar Products]
NCBI Protein Information
B-cell receptor CD22
UniProt Protein Name
B-cell receptor CD22
UniProt Synonym Protein Names
B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22
Protein Family
B-cell receptor
UniProt Gene Name
Cd22 [Similar Products]
UniProt Synonym Gene Names
Lyb-8; Siglec2; BL-CAM; Siglec-2 [Similar Products]
UniProt Comments for CD22
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Research Articles on CD22
1. Thus, proximity labeling with tyramide appears to be a useful method to identify cis-ligands and to analyze their interaction with the lectins.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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