Product Name
BCMA (TNFRSF17), Polyclonal Antibody
Full Product Name
BCMA Polyclonal Antibody
Product Synonym Names
BCMA
Product Gene Name
anti-TNFRSF17 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (12058964..12061925). Location: 16p13.1
3D Structure
ModBase 3D Structure for Q02223
Specificity
BCMA [Rabbit polyclonal antibody to BCMA]
This antibody recognizes human BCMA (B Cell Maturation Protein). BCMA is a receptor for BAFF and April, two novel members of the TNF superfamily of proteins regulating immune response and the induction of apoptosis through the activation of NF- kappa B and c-jun Nterminal kinase.
Form/Format
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Antigen
A synthetic peptide corresponding to the carboxy terminus of human BCMA.
Preservatives
0.02% sodium azide
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
Store at 4 degree C; stable for one year
Other Notes
Small volumes of anti-TNFRSF17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TNFRSF17 antibody
Growth Factors/Cytokines/Receptor Antibodies
Applications Tested/Suitable for anti-TNFRSF17 antibody
Western Blot
Application Notes for anti-TNFRSF17 antibody
Western Blot: Use at 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control.
NCBI/Uniprot data below describe general gene information for TNFRSF17. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q02223
[Other Products]
UniProt Related Accession #
Q02223; Q13808; Q2TQ40; Q6PE46[Other Products]
Molecular Weight
20,165 Da[Similar Products]
NCBI Official Full Name
BCMA
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 17
NCBI Official Symbol
TNFRSF17 [Similar Products]
NCBI Official Synonym Symbols
BCM; BCMA; CD269
[Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 17; OTTHUMP00000160261; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names
B-cell maturation protein
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF17 [Similar Products]
UniProt Synonym Gene Names
BCM; BCMA [Similar Products]
UniProt Entry Name
TNR17_HUMAN
NCBI Summary for TNFRSF17
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq]
UniProt Comments for TNFRSF17
TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p13.1
Cellular Component: plasma membrane; integral to membrane; endomembrane system
Molecular Function: receptor activity
Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
Research Articles on TNFRSF17
1. Signaling through BCMA enhances B cell activation following exposure to TLR9 agonists, and increased expression in SLE may contribute to the production of IgG autoantibodies.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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