Product Name
BCMA (TNFRSF17), Monoclonal Antibody
Full Product Name
BCMA (B Cell Maturation Protein)
Product Synonym Names
Anti -BCMA (B Cell Maturation Protein)
Product Gene Name
anti-TNFRSF17 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (12058964..12061925). Location: 16p13.1
3D Structure
ModBase 3D Structure for Q02223
Specificity
Recognizes mouse BCMA. Does not cross-react with human BCMA.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Immunogen
Recombinant mouse BCMA:Fc. The extracellular domain of mouse BCMA (aa 1-46) is fused at the C-terminus to a linker peptide (2 aa) and the Fc portion of human IgG1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-TNFRSF17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNFRSF17 antibody
BCMA is a member of the TNF receptor superfamily. It binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines. It plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184aa type I transmembrane protein, which contains a 54aa extracellular domain, a 23aa transmembrane domain, and a 107aa extracellular domain.
Product Categories/Family for anti-TNFRSF17 antibody
Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-TNFRSF17 antibody
Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-TNFRSF17 antibody
Suitable for use in Immunoprecipitation, Flow Cytometry, Western Blot and Functional Application.
Dilution: Immunoprecipitation: 1:200
Flow Cytometry: 1:1000
Western Blot: 1:1000
Functional Application: Blocks binding of BAFF to mouse BCMA.
NCBI/Uniprot data below describe general gene information for TNFRSF17. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q02223
[Other Products]
UniProt Related Accession #
Q02223; Q13808; Q2TQ40; Q6PE46[Other Products]
Molecular Weight
20,165 Da[Similar Products]
NCBI Official Full Name
BCMA
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 17
NCBI Official Symbol
TNFRSF17 [Similar Products]
NCBI Official Synonym Symbols
BCM; BCMA; CD269
[Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 17; OTTHUMP00000160261; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names
B-cell maturation protein
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF17 [Similar Products]
UniProt Synonym Gene Names
BCM; BCMA [Similar Products]
UniProt Entry Name
TNR17_HUMAN
NCBI Summary for TNFRSF17
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq]
UniProt Comments for TNFRSF17
TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p13.1
Cellular Component: integral to membrane; plasma membrane; endomembrane system
Molecular Function: receptor activity
Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
Research Articles on TNFRSF17
1. Signaling through BCMA enhances B cell activation following exposure to TLR9 agonists, and increased expression in SLE may contribute to the production of IgG autoantibodies.
Precautions
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Disclaimer
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