Full Product Name
SGLT1 Antibody FITC-Conjugated
Product Synonym Names
D22S675; High affinity sodium glucose cotransporter 1; Human Na+/glucose cotransporter 1; NAGT; SGLT 1; SLC5A1; Sodium glucose cotransporter 1; Solute carrier family 5 member 1 antibody
Product Gene Name
anti-SGLT1 antibody
[Similar Products]
Antibody/Peptide Pairs
SGLT1 peptide (MBS544462) is used for blocking the activity of SGLT1 antibody (MBS544865)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13866
Species Reactivity
Human, Monkey, Mouse, Pig, Rat
Form/Format
FITC-Conjugated
Concentration
0.6 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide corresponding to amino acids 402-422 of Human SGLT1.
Expression
Expessed mainly in intestine and kidney.
Determinant
Mid-Region Epitope
Molecular Function
glucose:sodium symporter activity
Structure
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Subcellular Location
Membrane
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-SGLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SGLT1 antibody
FITC-Conjugated Sodum/glucose cotransporter 1 Antibody Mid-Region
Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1.
Applications Tested/Suitable for anti-SGLT1 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-SGLT1 antibody
Confocal Microscopy||1:250
Dot Blot: 1:4,000
ELISA: 1:4,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:200
Western Blot: 1:500-1:1,000
NCBI/Uniprot data below describe general gene information for SGLT1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000334.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000343.3
[Other Products]
UniProt Primary Accession #
P13866
[Other Products]
UniProt Secondary Accession #
B2R7E2; B7Z4Q9; B7ZA69[Other Products]
UniProt Related Accession #
P13866[Other Products]
Molecular Weight
60,097 Da
NCBI Official Full Name
sodium/glucose cotransporter 1 isoform 1
NCBI Official Synonym Full Names
solute carrier family 5 member 1
NCBI Official Symbol
SLC5A1 [Similar Products]
NCBI Official Synonym Symbols
NAGT; SGLT1; D22S675
[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 1
UniProt Protein Name
Sodium/glucose cotransporter 1
UniProt Synonym Protein Names
High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
UniProt Gene Name
SLC5A1 [Similar Products]
UniProt Synonym Gene Names
NAGT; SGLT1; Na(+)/glucose cotransporter 1 [Similar Products]
UniProt Entry Name
SC5A1_HUMAN
NCBI Summary for SGLT1
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for SGLT1
SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: apical plasma membrane; brush border membrane; integral to plasma membrane; intercellular junction; plasma membrane
Molecular Function: glucose:sodium symporter activity; protein binding
Biological Process: D-glucose absorption; glucose transport; hexose transport; sodium ion transport
Disease: Glucose/galactose Malabsorption
Research Articles on SGLT1
1. Compound K induces SGLT1 expression and glucose uptake in differentiated intestinal Caco-2 cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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