Product Name
SGLT1 (SLC5A1), Polyclonal Antibody
Full Product Name
Anti-SGLT1 antibody
Product Synonym Names
Sodium/glucose cotransporter 1; solute carrier family 5(sodium/glucose cotransporter), member 1; D22S675 antibody; High affinity sodium glucose cotransporter 1 antibody; High affinity sodium glucose cotransporter antibody; High affinity sodium-glucose cotransporter antibody; Human Na+/glucose cotransporter 1 antibody; Na(+)/glucose cotransporter 1 antibody; Na+/glucose cotransporter 1 antibody; NAGT antibody; SC5A1_HUMAN antibody; SGLT 1 antibody; SGLT1 antibody; SLC5A1 antibody; Sodium glucose cotransporter 1 antibody; Sodium/glucose cotransporter 1 antibody; Solute carrier family 5(sodium/glucose cotransporter) member 1 antibody; Solute carrier family 5 member 1 antibody
Product Gene Name
anti-SLC5A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13866
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen affinity purified.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse SGLT1 (620-635aa KMTKEEEEAMKMKMTD), different from the related rat sequence by one amino acid, and from the related human sequence by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SLC5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC5A1 antibody
Description: Rabbit IgG polyclonal antibody for Sodium/glucose cotransporter 1(SLC5A1) detection. Tested with WB in Human, Mouse, Rat.
Background: Sodium/glucose cotransporter 1(SLC5A1), also known as NAGT or SGLT1 is a protein that in humans is encoded by the SLC5A1 gene. This gene is mapped to 22q12.3. This gene encodes a member of the sodium-dependent glucose transporter(SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-SLC5A1 antibody
Western Blot (WB)
Western Blot (WB) of anti-SLC5A1 antibody
Anti-SGLT1 antibody, MBS177060, Western blotting
Lane 1: Rat Kidney Tissue Lysate
Lane 2: Rat Heart Tissue Lysate
Lane 3: HELA Cell Lysate
Lane 4: SW620 Cell Lysate
Lane 5: COLO320 Cell Lysate
NCBI/Uniprot data below describe general gene information for SLC5A1. It may not necessarily be applicable to this product.
NCBI Accession #
P13866.1
[Other Products]
UniProt Primary Accession #
P13866
[Other Products]
UniProt Secondary Accession #
B2R7E2; B7Z4Q9; B7ZA69[Other Products]
UniProt Related Accession #
P13866[Other Products]
Molecular Weight
60,097 Da
NCBI Official Full Name
Sodium/glucose cotransporter 1
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Official Symbol
SLC5A1 [Similar Products]
NCBI Official Synonym Symbols
NAGT; SGLT1; D22S675
[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 1; Na+/glucose cotransporter 1; high affinity sodium-glucose cotransporter
UniProt Protein Name
Sodium/glucose cotransporter 1
UniProt Synonym Protein Names
High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
SLC5A1 [Similar Products]
UniProt Synonym Gene Names
NAGT; SGLT1; Na(+)/glucose cotransporter 1 [Similar Products]
UniProt Entry Name
SC5A1_HUMAN
NCBI Summary for SLC5A1
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for SLC5A1
SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; intercellular junction
Molecular Function: protein binding; glucose:sodium symporter activity
Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; pathogenesis; glucose transport; metanephros development; transmembrane transport; intestinal absorption
Disease: Glucose/galactose Malabsorption
Research Articles on SLC5A1
1. SGLT1 mRNA and GLUT2 mRNA expression are reduced significantly in CACo-2 cells exposed to berry extracts.
Precautions
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Disclaimer
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