Full Product Name
Anti-c-Myc Rabbit pAb
Product Synonym Names
AU016757; Avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; Class E basic helix-loop-helix protein 39; MRTL; Myc; Myc protein; Myc proto oncogene protein; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; MYC_HUMAN; Myc2; MYCC; Myelocytomatosis oncogene; Niard; Nird; Oncogene Myc; OTTHUMP00000158589; Proto-oncogene c-Myc; Protooncogene homologous to myelocytomatosis virus; RNCMYC; Transcription factor p64; Transcriptional regulator Myc-A; V-Myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian)
Product Gene Name
anti-MYC antibody
[Similar Products]
Product Synonym Gene Name
MRTL; MYCC; c-Myc; bHLHe39[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01106
Species Reactivity
Human, Mouse, Rat, Monkey
Purity/Purification
Affinity Purified
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from c-Myc. at AA range: 360-440.
Subcellular Location
Nucleus; Nucleolus
Other Notes
Small volumes of anti-MYC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MYC antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-MYC antibody
WB: 1:500-1:2000
IHC: 1:100-1:300
IF: 1:200-1:1000
ELISA: 1:40000
Western Blot (WB) of anti-MYC antibody
Western Blot analysis of HuvEc cells using c-Myc Polyclonal Antibody
Western Blot (WB) of anti-MYC antibody
Western Blot analysis of various cells using c-Myc Polyclonal Antibody
NCBI/Uniprot data below describe general gene information for MYC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002458.2
[Other Products]
NCBI GenBank Nucleotide #
NM_002467.5
[Other Products]
UniProt Primary Accession #
P01106
[Other Products]
UniProt Secondary Accession #
P01107; Q14026; A8WFE7[Other Products]
UniProt Related Accession #
P01106[Other Products]
Molecular Weight
57-65kDa
NCBI Official Full Name
myc proto-oncogene protein isoform 1
NCBI Official Synonym Full Names
MYC proto-oncogene, bHLH transcription factor
NCBI Official Symbol
MYC [Similar Products]
NCBI Official Synonym Symbols
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
NCBI Protein Information
myc proto-oncogene protein
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family
C-Myc-binding protein
UniProt Gene Name
MYC [Similar Products]
UniProt Synonym Gene Names
BHLHE39; bHLHe39 [Similar Products]
NCBI Summary for MYC
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
UniProt Comments for MYC
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).
Research Articles on MYC
1. cMyc promotes rhabdomyosarcoma development by inhibiting apoptosis through repression of p21 transcription.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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