Product Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), Recombinant Protein
Full Product Name
Recombinant Rat 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) , partial
Product Gene Name
Hmgcr recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTAEQSKVS LGLAEDVSKR IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QAETESTLSL KNPITSPVVT PKKAQDNCCR REPLLVRRNQ KLSSVEEDPG VNQDRKVEVI KPLVAEAETS GRATFVLGAS AASPPLALGA QEPGIELPSE PRPNEECLQI LESAEKGAKF LSDAEIIQLV NAKHIPAYKL ETLMETHERG VSIRRQLLSA KLAEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA GPLCLDGKEY QVPMATTEGC LVASTNRGCR AISLGGGASS RVLADGMSRG PVVRLPRACD SAEVKSWLET PEGFAVVKEA FDSTSRFARL QKLHVTLAGR NLYIRLQSKT GDAMGMNMIS KGTEKALLKL QEFFPELQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL KTTTEAMVDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKAA
3D Structure
ModBase 3D Structure for P51639
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hmgcr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Hmgcr. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037266.2
[Other Products]
NCBI GenBank Nucleotide #
NM_013134.2
[Other Products]
UniProt Primary Accession #
P51639
[Other Products]
UniProt Secondary Accession #
Q64601; Q6P2A6[Other Products]
UniProt Related Accession #
P51639[Other Products]
Molecular Weight
96,688 Da
NCBI Official Full Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA reductase
NCBI Official Symbol
Hmgcr [Similar Products]
NCBI Official Synonym Symbols
3H3M
[Similar Products]
NCBI Protein Information
3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt Gene Name
Hmgcr [Similar Products]
UniProt Synonym Gene Names
HMG-CoA reductase [Similar Products]
NCBI Summary for Hmgcr
enzyme involved in mevalonate synthesis [RGD, Feb 2006]
UniProt Comments for Hmgcr
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Research Articles on Hmgcr
1. findings demonstrate for the first time that strain-dependent sex difference in serum Total Cholesterol level between F344 and SD rats is, at least in part, related to difference in the IL-1alpha-mediated HMGR gene expression level in the liver.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
