SLC5A1 / SGLT1, Polyclonal Antibody

Anti-SLC5A1 / SGLT1 Antibody (Internal) IHC-plus; SLC5A1; D22S675; HSGLT1; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; SGLT1; NAGT; Sodium-glucose transporter 1; Sodium/glucose cotransporter 1; Human SLC5A1; SGLT1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human SLC5A1 / SGLT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml (lot specific)

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-SLC5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Solute Carrier Family 5 Member 1 (Slc5a1/SGLT1) is a member of the sodium dependent glucose transporters also known as co transporters or symporters. It is an integral membrane protein involved in the active transport of glucose and galactose across the membrane of cells lining the gi tract and kidney. Transport is driven by the sodium/potassium ATPase.

Subfamily:-Solute:sodium-symporter">Family: Transporter
Subfamily: Solute:sodium symporter

Immunohistochemistry (IHC - Paraffin)

IHC-P (5 - 10 ug/ml)

Anti-SLC5A1 / SGLT1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC5A1 / SGLT1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

60,097 Da

solute carrier family 5 (sodium/glucose cotransporter), member 1

sodium/glucose cotransporter 1; Na+/glucose cotransporter 1; high affinity sodium-glucose cotransporter

Sodium/glucose cotransporter 1

NAGT; SGLT1; Na(+)/glucose cotransporter 1  [Similar Products]

SC5A1_HUMAN

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; intercellular junction

Molecular Function: protein binding; glucose:sodium symporter activity

Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; pathogenesis; glucose transport; transmembrane transport; metanephros development; intestinal absorption

Disease: Glucose/galactose Malabsorption

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