c-Myc, Blocking Peptide

BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

For Research Use Only. Not for use in diagnostic procedures.

Synthetic

>85%

Lyophilized Powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Small volumes of MYC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The peptide is used to block Anti-c-Myc reactivity.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

50,565 Da

v-myc avian myelocytomatosis viral oncogene homolog

myc proto-oncogene protein

Myc proto-oncogene protein

BHLHE39; bHLHe39  [Similar Products]

MYC_HUMAN

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: Nucleolus; Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding; protein complex binding; protein dimerization activity; transcription factor activity; transcription factor binding

Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; energy reserve metabolic process; gene expression; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; oxygen transport; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression; regulation of telomere maintenance; response to DNA damage stimulus; response to drug; response to gamma radiation; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin

Disease: Burkitt Lymphoma

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