Full Product Name
Anti-Phospho-c-Myc (T58 + S62) Rabbit pAb
Product Synonym Names
Myc proto-oncogene protein; c-myc
Product Gene Name
anti-c-Myc antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01106
Species Reactivity
Human, Rat
Specificity
Phospho-c-Myc (T58 + S62) Antibody detects endogenous levels of total Phospho-c-Myc (T58 + S62)
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Phospho-c-Myc (T58 + S62)
Subcellular Location
Nucleus; Nucleolus
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-c-Myc antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-c-Myc antibody
Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.
Applications Tested/Suitable for anti-c-Myc antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-c-Myc antibody
WB: 1:500-1:2000
ICC/IF: 1:100-1:200
IP: 1:50
Western Blot (WB) of anti-c-Myc antibody
Western blot analysis of Phospho-c-Myc (T58 + S62) in HEK293 cell lysate treated with EGF.
NCBI/Uniprot data below describe general gene information for c-Myc. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002458.2
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NCBI GenBank Nucleotide #
NM_002467.5
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UniProt Primary Accession #
P01106
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UniProt Secondary Accession #
P01107; Q14026; A8WFE7[Other Products]
UniProt Related Accession #
P01106[Other Products]
NCBI Official Full Name
myc proto-oncogene protein isoform 1
NCBI Official Synonym Full Names
MYC proto-oncogene, bHLH transcription factor
NCBI Official Symbol
MYC [Similar Products]
NCBI Official Synonym Symbols
MRTL; MYCC; c-Myc; bHLHe39
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NCBI Protein Information
myc proto-oncogene protein
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family
C-Myc-binding protein
UniProt Gene Name
MYC [Similar Products]
UniProt Synonym Gene Names
BHLHE39; bHLHe39 [Similar Products]
NCBI Summary for c-Myc
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
UniProt Comments for c-Myc
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).
Research Articles on c-Myc
1. cMyc promotes rhabdomyosarcoma development by inhibiting apoptosis through repression of p21 transcription.
Precautions
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Disclaimer
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