Full Product Name
C-Myc Antibody BIOTIN-Conjugated
Product Synonym Names
AU016757; Avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; Cellular myelocytomatosis oncogene; Class E basic helix-loop-helix protein 39; MRTL; Myc; Myc protein; Myc proto oncogene protein; myc-related translation/localization regulatory factor; MYCC; Myelocytomatosis oncogene; Niard; Nird; Oncogene Myc; Proto-oncogene c-Myc; Protooncogene homologous to myelocytomatosis virus; RNCMYC; Transcription factor p64; Transcriptional regulator Myc-A; V-Myc avian myelocytomatosis viral oncogene homolog antibody
Product Gene Name
anti-C-Myc antibody
[Similar Products]
Antibody/Peptide Pairs
C-Myc peptide (MBS542970) is used for blocking the activity of C-Myc antibody (MBS541299)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01106
Species Reactivity
Cat, Human, Monkey
Form/Format
BIOTIN-Conjugated
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 400-454 on human cMyc protein.
Molecular Function
Activator; Transcription regulation; DNA-binding
Structure
Contains 1 basic helix-loop-helix domain
Subcellular Location
Nucleus
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-C-Myc antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C-Myc antibody
BIOTIN-Conjugated myc proto-oncogene protein Antibody C-epitope
Transcription factor that binds DNA in non-specific manner. Also specifically recognizes the core sequence 5'CAC[GA]TG-3'. Activates transcription of growth-related genes.
Applications Tested/Suitable for anti-C-Myc antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-C-Myc antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for C-Myc. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002458
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NCBI GenBank Nucleotide #
NM_002467.4
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UniProt Primary Accession #
P01106
[Other Products]
UniProt Secondary Accession #
P01107; Q14026; A8WFE7[Other Products]
UniProt Related Accession #
P01106[Other Products]
Molecular Weight
50,565 Da
NCBI Official Full Name
myc proto-oncogene protein
NCBI Official Synonym Full Names
v-myc avian myelocytomatosis viral oncogene homolog
NCBI Official Symbol
MYC [Similar Products]
NCBI Official Synonym Symbols
MRTL; MYCC; c-Myc; bHLHe39
[Similar Products]
NCBI Protein Information
myc proto-oncogene protein
UniProt Protein Name
Myc proto-oncogene protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Protein Family
C-Myc-binding protein
UniProt Gene Name
MYC [Similar Products]
UniProt Synonym Gene Names
BHLHE39; bHLHe39 [Similar Products]
UniProt Entry Name
MYC_HUMAN
NCBI Summary for C-Myc
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for C-Myc
Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.
Protein type: Transcription factor; Nucleolus; Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 8q24.21
Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: DNA binding; protein binding; protein complex binding; protein dimerization activity; transcription factor activity; transcription factor binding
Biological Process: cell cycle arrest; cellular iron ion homeostasis; chromatin remodeling; chromosome organization and biogenesis; energy reserve metabolic process; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; oxygen transport; positive regulation of caspase activity; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression; regulation of telomere maintenance; response to DNA damage stimulus; response to drug; response to gamma radiation; transcription from RNA polymerase II promoter; ureteric bud branching; Wnt receptor signaling pathway through beta-catenin
Disease: Burkitt Lymphoma
Research Articles on C-Myc
1. MicoRNA-451 is a novel tumor suppressor via targeting c-myc in head and neck squamous cell carcinomas
Precautions
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Disclaimer
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