ABCD4, Antibody

ATP-binding cassette sub-family D member 4; Peroxisomal membrane protein 69; PMP69; Peroxisomal membrane protein 1-like; PXMP1-L; P70R

For Research Use Only. Not for use in diagnostic procedures.

ABCD4 Antibody detects endogenous levels of total ABCD4

Immunogen affinity purified

In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C. Stable for 12 months from date of receipt.

Small volumes of anti-ABCD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:1000
IHC: 1:50-1:200

Western blot analysis of extracts from HepG2 cells, using ABCD4 antibody.

70 KD

ATP binding cassette subfamily D member 4

ATP-binding cassette sub-family D member 4

ATP-binding cassette sub-family D member 4

PXMP1L; P70R; PXMP1-L; PMP69  [Similar Products]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017]

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.

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