Dimethylglycine dehydrogenase, ELISA Kit

Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; Dmgdh; 1.5.8.4

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of Dmgdh elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS288693 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dimethylglycine dehydrogenase (Dmgdh) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Dmgdh. The ELISA analytical biochemical technique of the MBS288693 kit is based on Dmgdh antibody-Dmgdh antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Dmgdh antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Dmgdh. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

97,255 Da

dimethylglycine dehydrogenase precursor

dimethylglycine dehydrogenase, mitochondrial

Dimethylglycine dehydrogenase, mitochondrial

M2GD_MOUSE

This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]

DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family.

Protein type: Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine; EC 1.5.8.4; Mitochondrial

Cellular Component: mitochondrion

Molecular Function: dimethylglycine dehydrogenase activity; FAD binding; folic acid binding; oxidoreductase activity

Biological Process: glycine metabolic process

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