Full Product Name
Rabbit DMGDH Antibody
Product Gene Name
anti-DMGDH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (78293429..78365449, complement). Location: 5q14.1
3D Structure
ModBase 3D Structure for Q9UI17
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-DMGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DMGDH antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DMGDH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037523.2
[Other Products]
NCBI GenBank Nucleotide #
NM_013391.2
[Other Products]
UniProt Primary Accession #
Q9UI17
[Other Products]
UniProt Secondary Accession #
B2RBN0[Other Products]
UniProt Related Accession #
Q9UI17[Other Products]
Molecular Weight
96,811 Da
NCBI Official Full Name
dimethylglycine dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
dimethylglycine dehydrogenase
NCBI Official Symbol
DMGDH [Similar Products]
NCBI Official Synonym Symbols
DMGDHD; ME2GLYDH
[Similar Products]
NCBI Protein Information
dimethylglycine dehydrogenase, mitochondrial
UniProt Protein Name
Dimethylglycine dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ME2GLYDH
Protein Family
Dimethylglycine dehydrogenase
UniProt Gene Name
DMGDH [Similar Products]
UniProt Entry Name
M2GD_HUMAN
NCBI Summary for DMGDH
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. [provided by RefSeq, Jul 2008]
UniProt Comments for DMGDH
DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family.
Protein type: Oxidoreductase; EC 1.5.8.4; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonine
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: mitochondrial matrix
Molecular Function: electron carrier activity; dimethylglycine dehydrogenase activity
Biological Process: glycine metabolic process; choline metabolic process; betaine catabolic process
Disease: Dimethylglycine Dehydrogenase Deficiency
Research Articles on DMGDH
1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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