Cohesin subunit SA-2 (STAG2), Polyclonal Antibody

SA2; Cohesin subunit SA-2; SCC3 homolog 2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>=90% by SDS-PAGE

Lyophilized or Liquid

1 mg/mL (lot specific)

Small volumes of anti-STAG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SDS-PAGE; Western Blot (WB); ELISA (EIA)

145,751 Da

stromal antigen 2

cohesin subunit SA-2

Cohesin subunit SA-2

SA2  [Similar Products]

The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

STAG2: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: actin cytoskeleton; chromatin; chromosome; chromosome, pericentric region; cytosol; intermediate filament cytoskeleton; membrane; nucleolus; nucleoplasm; nucleus; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of DNA endoreduplication; protein sumoylation; sister chromatid cohesion

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