Product Name
FAM134B, Polyclonal Antibody
Full Product Name
FAM134B Antibody, FITC conjugated
Product Synonym Names
Reticulophagy receptor FAM134B; FAM134B
Product Gene Name
anti-FAM134B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H6L5
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Reticulophagy receptor FAM134B protein (1-131AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-101986 / sc-131955 / sc-131956
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-FAM134B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FAM134B antibody
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed: 26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed: 26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed: 19838196, PubMed: 26040720).
Applications Tested/Suitable for anti-FAM134B antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FAM134B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001030022.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001034850.2
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UniProt Primary Accession #
Q9H6L5
[Other Products]
UniProt Secondary Accession #
Q69YN8; Q9H6K6; Q9H764; Q9NXM8[Other Products]
UniProt Related Accession #
Q9H6L5[Other Products]
Molecular Weight
39,317 Da
NCBI Official Full Name
reticulophagy receptor FAM134B isoform 1
NCBI Official Synonym Full Names
family with sequence similarity 134 member B
NCBI Official Symbol
FAM134B [Similar Products]
NCBI Official Synonym Symbols
JK1; JK-1
[Similar Products]
NCBI Protein Information
reticulophagy receptor FAM134B
UniProt Protein Name
Reticulophagy receptor FAM134B
Protein Family
Reticulophagy receptor
UniProt Gene Name
FAM134B [Similar Products]
UniProt Entry Name
F134B_HUMAN
NCBI Summary for FAM134B
The protein encoded by this gene is a cis-Golgi transmembrane protein that may be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Mutations in this gene are a cause of hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), and this gene may also play a role in susceptibility to vascular dementia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for FAM134B
FAM134B: Required for long-term survival of nociceptive and autonomic ganglion neurons. Defects in FAM134B are the cause of hereditary sensory and autonomic neuropathy type 2B (HSAN2B). A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2B is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation. Onset occurs in the first or second decade, with impaired nociception and progressive mutilating ulceration of the hands and feet with osteomyelitis and acroosteolysis. Amputations of the hands and feet are common. Autonomic dysfunction includes hyperhidrosis, urinary incontinence, and slow pupillary light response. Belongs to the FAM134 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5p15.1
Cellular Component: cis-Golgi network; integral to endoplasmic reticulum membrane
Molecular Function: protein binding
Biological Process: negative regulation of neuron apoptosis; sensory perception of pain
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Research Articles on FAM134B
1. selective endoplasmic reticulum (ER)-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans
Precautions
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Disclaimer
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