ELKS/RAB6-interacting/CAST family member 1, ELISA Kit

Rat ELKS/Rab6-interacting/CAST family member 1 (ERC1) ELISA kit; Cast2; ELKS; FLJ31750; KIAA1081; MGC12974; RAB6IP2; OTTHUMP00000160633; RAB6 interacting protein 2; RAB6-interacting protein 2; Rab6-interacting protein 2; ELKS/RAB6-interacting/CAST family member 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of ERC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9322451 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ELKS/RAB6-interacting/CAST family member 1 (ERC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ERC1. The ELISA analytical biochemical technique of the MBS9322451 kit is based on ERC1 antibody-ERC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

108,818 Da

ELKS/RAB6-interacting/CAST family member 1

ELKS/Rab6-interacting/CAST family member 1; ERC-1; ERC protein 1; RIM-Binding Protein; Rab6 interacting protein 2; Rab6-interacting protein 2; CAZ-associated structural protein 2

ELKS/Rab6-interacting/CAST family member 1

Cast2; Elks; Rab6ip2; ERC-1; CAST2  [Similar Products]

RB6I2_RAT

bind to the conserved PDZ domain of presynaptic active zone proteins termed RIMs [RGD, Feb 2006]

ERC1: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: Golgi membrane; cytoplasm; synapse; IkappaB kinase complex

Molecular Function: protein binding; Rab GTPase binding; PDZ domain binding

Biological Process: protein transport; I-kappaB phosphorylation; retrograde transport, endosome to Golgi

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