Full Product Name
MC2R Polyclonal Antibody
Product Synonym Names
ACTHR
Product Gene Name
anti-MC2R antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.1mg/mL (lot specific)
Immunogen
Synthetic peptide of human MC2R
Calculated Molecular Weight: 34kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MC2R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MC2R antibody
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
Applications Tested/Suitable for anti-MC2R antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-MC2R antibody
WB: 1:1000-1:5000
Western Blot (WB) of anti-MC2R antibody
Western Blot analysis of Human fetal kidney tissue using MC2R Polyclonal Antibody at dilution of 1:1400
NCBI/Uniprot data below describe general gene information for MC2R. It may not necessarily be applicable to this product.
NCBI Accession #
AAI04171.1
[Other Products]
UniProt Secondary Accession #
Q3MI45; Q504X6; A8K016[Other Products]
UniProt Related Accession #
Q01718[Other Products]
Molecular Weight
33,927 Da
NCBI Official Full Name
MC2R protein, partial
NCBI Official Synonym Full Names
melanocortin 2 receptor (adrenocorticotropic hormone)
NCBI Official Symbol
MC2R [Similar Products]
NCBI Official Synonym Symbols
ACTHR
[Similar Products]
NCBI Protein Information
adrenocorticotropic hormone receptor; ACTH receptor; MC2 receptor; adrenocorticotropin receptor
UniProt Protein Name
Adrenocorticotropic hormone receptor
UniProt Synonym Protein Names
Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R
Protein Family
Adrenocorticotropic hormone receptor
UniProt Gene Name
MC2R [Similar Products]
UniProt Synonym Gene Names
ACTHR; ACTH receptor; ACTH-R; MC2-R [Similar Products]
UniProt Entry Name
ACTHR_HUMAN
NCBI Summary for MC2R
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
UniProt Comments for MC2R
MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 18p11.2
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development
Disease: Glucocorticoid Deficiency 1
Research Articles on MC2R
1. MC2R overexpression is associated with myelolipomas.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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