2", 5"-Oligoadenylate Synthetase 2 (OAS2), Monoclonal Antibody

p69 OAS / p71 OAS

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2b kappa

C1

Mouse

The antibody is a mouse monoclonal antibody raised against OAS2. It has been selected for its ability to recognize OAS2 in immunohistochemical staining and western blotting.

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Liquid

500ug/ml (lot specific)

Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-OAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

2'-5'-oligoadenylate synthetase 2

2'-5'-oligoadenylate synthase 2

2'-5'-oligoadenylate synthase 2

(2-5')oligo(A) synthase 2; 2-5A synthase 2; p69OAS / p71OAS  [Similar Products]

OAS2_HUMAN

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: mitochondrion; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; RNA catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; protein myristoylation; protein amino acid glycosylation; purine nucleotide biosynthetic process; defense response to virus

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