Product Name
LINGO-1 (LINGO1), Polyclonal Antibody
Full Product Name
LINGO-1, CT (S596) (LRRN6A) (Lingo1, Lern1, Lrrn6a, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A)
Product Synonym Names
Anti -LINGO-1, CT (S596) (LRRN6A) (Lingo1, Lern1, Lrrn6a, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A)
Product Gene Name
anti-LINGO1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 15; NC_000015.9 (77905369..77988490, complement). Location: 15q24.3
3D Structure
ModBase 3D Structure for Q96FE5
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
LINGO-1(LRRN6A)-S596 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 583-613 amino acids from the C-terminal region of human LINGO-1(LRRN6A).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-LINGO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LINGO1 antibody
LINGO-1 is functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. LINGO-1 is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Product Categories/Family for anti-LINGO1 antibody
Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-LINGO1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LINGO1 antibody
Suitable for use in Western Blot, Immunohistochemistry
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
NCBI/Uniprot data below describe general gene information for LINGO1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_116197.4
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NCBI GenBank Nucleotide #
NM_032808.5
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UniProt Primary Accession #
Q96FE5
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UniProt Secondary Accession #
Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80[Other Products]
UniProt Related Accession #
Q96FE5[Other Products]
Molecular Weight
69,876 Da[Similar Products]
NCBI Official Full Name
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
NCBI Official Synonym Full Names
leucine rich repeat and Ig domain containing 1
NCBI Official Symbol
LINGO1 [Similar Products]
NCBI Official Synonym Symbols
LERN1; LRRN6A; UNQ201
[Similar Products]
NCBI Protein Information
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat neuronal protein 6A; leucine-rich repeat and immunoglobilin domain-containing protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
UniProt Protein Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Synonym Protein Names
Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
Protein Family
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
UniProt Gene Name
LINGO1 [Similar Products]
UniProt Synonym Gene Names
LERN1; LRRN6A [Similar Products]
UniProt Entry Name
LIGO1_HUMAN
UniProt Comments for LINGO1
LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: plasma membrane; integral to membrane
Molecular Function: epidermal growth factor receptor binding
Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
Research Articles on LINGO1
1. This study demonistrated that theLINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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