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CHEK2 / CHK2, Polyclonal Antibody

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产品名称: CHEK2 / CHK2, Polyclonal Antibody
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简单介绍

CHEK2 / CHK2, Polyclonal Antibody


CHEK2 / CHK2, Polyclonal Antibody  的详细介绍
Product Name

CHEK2 / CHK2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2

Product Synonym Names
Anti-CHEK2 / CHK2 Antibody (aa35-84) IHC-plus; CHEK2; BA444G7; Cds1 homolog; Checkpoint kinase 2; Checkpoint-like protein CHK2; CHK2 checkpoint homolog; CHK2; HCds1; LFS2; RAD53; Rad53 homolog; HCHK2; HuCds1; PP1425; Human CHEK2; CHK2
Product Gene Name

anti-CHEK2 antibody

[Similar Products]
Product Synonym Gene Name
CHK2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
gene+phenotype 609265
3D Structure
ModBase 3D Structure for O96017
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Chk2 (Ab-68) Antibody detects endogenous levels of total Chk2 protein.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human CHEK2 (aa35-84).
Immunogen
CHEK2 / CHK2 antibody was raised against synthetic peptide from human CHEK2 (aa35-84).
Antigen Modification
aa35-84
Preparation and Storage
Store at -20 degree C for up to one year.
Other Notes
Small volumes of anti-CHEK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-CHEK2 antibody
CHK2 is a serine/threonine kinase in the CDS subfamily that is activated in response to DNA damage and may regulate cell cycle arrest. It is the human homolog of RAD53 in S. cerevisiae and CDS1 in S. pombe. The protein has a FHA domain, which means it is located in the nucleus. Its kinase activity is up regulated by autophosphorylation in response to DNA damage and to replication blocks.
Product Categories/Family for anti-CHEK2 antibody
Subfamily:-CDS1">Family: Protein Kinase
Subfamily: CDS1
Applications Tested/Suitable for anti-CHEK2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CHEK2 antibody
ELISA (1:10000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-CHEK2 antibody
Anti-CHEK2 / CHK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-CHEK2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-CHEK2 antibody
Western blot of extracts from Jurkat and HeLa cells treated with etoposide 25 uM 24hours, using Chk2 (Ab-68) Antibody. The lane on the right is treated with the synthesized peptide.
anti-CHEK2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CHEK2. It may not necessarily be applicable to this product.
NCBI GI #
6005850
NCBI GeneID
11200
NCBI Accession #
NP_009125.1 [Other Products]
NCBI GenBank Nucleotide #
NM_007194.3 [Other Products]
UniProt Primary Accession #
O96017 [Other Products]
UniProt Secondary Accession #
Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5[Other Products]
UniProt Related Accession #
O96017[Other Products]
Molecular Weight
36,157 Da
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NCBI Official Full Name
serine/threonine-protein kinase Chk2 isoform a
NCBI Official Synonym Full Names
checkpoint kinase 2
NCBI Official Symbol
CHEK2  [Similar Products]
NCBI Official Synonym Symbols
CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425
  [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase Chk2; cds1 homolog; CHK2 checkpoint homolog; checkpoint-like protein CHK2
UniProt Protein Name
Serine/threonine-protein kinase Chk2
UniProt Synonym Protein Names
CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
CHEK2  [Similar Products]
UniProt Synonym Gene Names
CDS1; CHK2; RAD53; Hucds1; hCds1  [Similar Products]
UniProt Entry Name
CHK2_HUMAN
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NCBI Summary for CHEK2
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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UniProt Comments for CHEK2
Chk2: a CAMK protein kinase of the Rad53 family. A cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. Phosphorylates and inhibits CDC25C, preventing entry into mitosis, p53, leading to cell cycle arrest in G1, and BRCA1, restoring survival after DNA damage. Twelve splice variant isoforms have been described for human Chk2. LOF mutants cause Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype also caused by p53 mutations. Familial mutations also associated with prostate and breast cancer, and mutations also seen in a variety of sporadic cancers and cell lines.

Protein type: Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; EC 2.7.11.1; CAMK group; RAD53 family

Chromosomal Location of Human Ortholog: 22q12.1

Cellular Component: nucleoplasm; Golgi apparatus; PML body; chromosome, telomeric region

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; metal ion binding; protein kinase binding; ATP binding

Biological Process: transcription, DNA-dependent; DNA damage induced protein phosphorylation; protein stabilization; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; DNA damage response, signal transduction; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; DNA damage response, signal transduction resulting in induction of apoptosis; cellular protein catabolic process; cell division; double-strand break repair; DNA damage checkpoint; response to gamma radiation; regulation of protein catabolic process; G2/M transition of mitotic cell cycle; response to DNA damage stimulus

Disease: Li-fraumeni Syndrome 2; Breast Cancer; Prostate Cancer; Osteogenic Sarcoma
Research Articles on CHEK2
1. Chromosomal instability is induced by overexpression of the oncogene AURKA or by loss of the tumour suppressor gene CHK2, a genetic constitution found in colorectal cancers.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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