Product Name
Necrostatin-1 (Pcsk1), Biochemical
Full Product Name
Necrostatin-1
Product Synonym Names
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1
Product Gene Name
Pcsk1 biochemical
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=98% by TLC
Form/Format
Appearance: Yellow solid
Solubility/Reconstitution Instructions
DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)
SMILES
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChi
InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Handling
Protect from air and light
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Other Notes
Small volumes of Pcsk1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Pcsk1 biochemical
Background: Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC?? = 180 nM).
Product Categories/Family for Pcsk1 biochemical
Apoptosis; Necroptosis Inhibitors and Biochemicals (A-Z)
Structure of Pcsk1 biochemical
NCBI/Uniprot data below describe general gene information for Pcsk1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038656.1
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NCBI GenBank Nucleotide #
NM_013628.2
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UniProt Secondary Accession #
P21662; P22546[Other Products]
UniProt Related Accession #
P63239[Other Products]
Molecular Weight
259.33[Similar Products]
NCBI Official Full Name
neuroendocrine convertase 1
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 1
NCBI Official Symbol
Pcsk1 [Similar Products]
NCBI Official Synonym Symbols
PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1
[Similar Products]
NCBI Protein Information
neuroendocrine convertase 1
UniProt Protein Name
Neuroendocrine convertase 1
UniProt Synonym Protein Names
Furin homolog; PC3; Prohormone convertase 1; Propeptide-processing protease; Proprotein convertase 1; PC1
Protein Family
Neuroendocrine convertase
UniProt Gene Name
Pcsk1 [Similar Products]
UniProt Synonym Gene Names
Att-1; Nec-1; Nec1; NEC 1; PC1 [Similar Products]
UniProt Entry Name
NEC1_MOUSE
UniProt Comments for Pcsk1
PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: Protease; EC 3.4.21.93
Cellular Component: Golgi apparatus; extracellular space; cytoplasmic vesicle
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity
Biological Process: peptide hormone processing; protein processing; proteolysis; peptide biosynthetic process
Research Articles on Pcsk1
1. Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme.
Precautions
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Disclaimer
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