Neuroendocrine convertase 1 (Pcsk1), Recombinant Protein

Neuroendocrine convertase 1; NEC 1; EC=3.4.21.93; Prohormone convertase 1; Proprotein convertase 1; PC1

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Pcsk1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Pcsk1; Bdp, Nec-1, Nec1

84,121 Da

proprotein convertase subtilisin/kexin type 1

neuroendocrine convertase 1; NEC 1; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I

Neuroendocrine convertase 1

Bdp; Nec-1; Nec1; NEC 1; PC1  [Similar Products]

NEC1_RAT

plays a role in proteolytic processing of peptide hormone and other protein precursors [RGD, Feb 2006]

PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily.

Protein type: Protease; EC 3.4.21.93

Cellular Component: extracellular space; neuron projection; transport vesicle; rough endoplasmic reticulum; cell soma; perinuclear region of cytoplasm; dendrite; perikaryon; nerve terminal; trans-Golgi network; secretory granule

Molecular Function: insulin binding; chaperone binding; serine-type endopeptidase activity; endopeptidase activity; protein complex binding

Biological Process: response to nutrient levels; response to drug; response to peptide hormone stimulus; response to inorganic substance; response to glucocorticoid stimulus; peptide hormone processing; response to morphine; response to lipopolysaccharide; proteolysis; response to organic cyclic substance; response to chlorate; peptide biosynthetic process; protein autoprocessing; positive regulation of protein secretion; neurogenesis; pituitary gland development; pancreas development; response to glucose stimulus; protein processing; response to axon injury; response to calcium ion

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