Product Name
PCSK1, cDNA Clone
Full Product Name
PCSK1 cDNA Clone
Product Gene Name
PCSK1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggagcgaa gagcctggag tctgcagtgc actgctttcg tcctcttttg cgcttggtgt gcactgaaca gtgcaaaagc gaaaaggcaa tttgtcaatg aatgggcagc ggagatcccc gggggcccgg aagcagcctc ggccatcgcc gaggagctgg gctatgacct tttgggtcag attggttcac ttgaaaatca ctacttattc aaacataaaa accaccccag aaggtctcga aggagtgcct ttcatatcac taagagatta tctgatgatg atcgtgtgat atgggctgaa caacagtatg aaaaagaaag aagtaaacgt tcagctctaa gggactcagc actaaatctc ttcaatgatc ccatgtggaa tcagcaatgg tacttgcaag ataccaggat gacggcagcc ctgcccaagc tggaccttca tgtgatacct gtttggcaaa aaggcattac gggcaaagga gttgttatca ccgtactgga tgatggtttg gagtggaatc acacggacat ttatgccaac tatgatccag aggctagcta tgattttaat gataatgacc atgatccatt tccccgatat gatcccacaa acgagaacaa acacgggacc agatgtgcag gagaaattgc catgcaagca aataatcaca aatgcggggt tggagttgca tacaattcca aagttggagg cataagaatg ctggatggca ttgtgacgga tgctattgag gccagttcaa ttggattcaa tcctggacac gtggatattt acagtgcaag ctggggccct aatgatgatg ggaaaactgt ggaggggcct ggccggctag cccagaaggc ttttgaatat ggtgtcaaac aggggagaca ggggaagggg tccatcttcg tctgggcttc gggaaacggg gggcgtcagg gagataattg tgactgtgat ggctacacag acagcatcta caccatctcc atcagcagtg cctcccagca aggcctatcc ccctggtacg ctgagaagtg ctcctccaca ctggccacct cttacagcag cggagattac accgaccaga gaatcacgag cgctgacctg cacaatgact gcacggagac gcacacaggc acctcggcct ctgcacctct ggctgctggc atcttcgctc tggccctgga agcaaaccca aatctcacct ggcgagatat gcagcacctg gttgtctgga cctctgagta tgacccgctg gccaataacc ctggatggaa aaagaatgga gcaggcttga tggtgaatag tcgatttgga tttggcttgc taaatgccaa agctctggtg gatttagctg accccaggac ctggaggagc gtgcctgaga agaaagagtg tgttgtaaag gacaatgact ttgagcccag agccctgaaa gctaatggag aagttatcat tgaaattcca acaagagctt gtgaaggaca agaaaatgct atcaagtccc tggagcatgt acaatttgaa gcaacaattg aatattcccg aagaggagac cttcatgtca cacttacttc tgctgctgga actagcactg tgctcttggc tgaaagagaa cgggatacat ctcctaatgg ctttaagaat tgggacttca tgtctgttca cacatgggga gagaacccta taggtacttg gactttgaga attacagaca tgtctggaag aattcaaaat gaaggaagaa ttgtgaactg gaagctgatt ttgcacggga cctcttctca gccagagcat atgaagcagc ctcgtgtgta cacgtcctac aacactgttc agaatgacag aagaggggtg gagaagatgg tggatccagg ggaggagcag cccacacaag agaaccctaa ggagaacacc ctggtgtcca aaagccccag cagcagcagc gtagggggcc ggagggatga gttggaggag ggagcccctt ccgaggccat gctgcgactc ctgcaaagtg ctttcagtaa aaactcaccg ccaaagcaat caccaaagaa gtccccaact gcaaagctca acatccctta tgaaaacttc tacgaagccc tggaaaagct gaacaaacct tcccagctta aagactctga agacagtctg tataatgact atgttgatgt tttttataac actaaacctt acaagcacag agacgaccgg ctgcttcaag ctctggtgga cattctgaat gaggaaaatt aa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PCSK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PCSK1. It may not necessarily be applicable to this product.
NCBI Accession #
BC130295
[Other Products]
UniProt Secondary Accession #
P78478; Q92532; B7Z8T7; E9PHA1[Other Products]
UniProt Related Accession #
P29120[Other Products]
Molecular Weight
79,010 Da
NCBI Official Full Name
Homo sapiens proprotein convertase subtilisin/kexin type 1, mRNA
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 1
NCBI Official Symbol
PCSK1 [Similar Products]
NCBI Official Synonym Symbols
PC1; PC3; NEC1; SPC3; BMIQ12
[Similar Products]
NCBI Protein Information
neuroendocrine convertase 1
UniProt Protein Name
Neuroendocrine convertase 1
UniProt Synonym Protein Names
Prohormone convertase 1; Proprotein convertase 1; PC1
Protein Family
Neuroendocrine convertase
UniProt Gene Name
PCSK1 [Similar Products]
UniProt Synonym Gene Names
NEC1; NEC 1; PC1 [Similar Products]
UniProt Entry Name
NEC1_HUMAN
NCBI Summary for PCSK1
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]
UniProt Comments for PCSK1
PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: EC 3.4.21.93; Protease
Chromosomal Location of Human Ortholog: 5q15-q21
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase activity
Biological Process: cell-cell signaling; metabolic process; peptide biosynthetic process; peptide hormone processing; protein processing; proteolysis
Disease: Body Mass Index Quantitative Trait Locus 12; Proprotein Convertase 1/3 Deficiency
Research Articles on PCSK1
1. these common variants in PCSK1 and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.
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Disclaimer
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