Full Product Name
OCA2 Antibody, HRP conjugated
Product Synonym Names
P protein; Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog; OCA2; D15S12; P
Product Gene Name
anti-OCA2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q04671
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human P protein (2-136AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-OCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OCA2 antibody
Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
Product Categories/Family for anti-OCA2 antibody
Tags & Cell Markers; Metabolism; Signal transduction
Applications Tested/Suitable for anti-OCA2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for OCA2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000266.2
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NCBI GenBank Nucleotide #
NM_000275.2
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UniProt Primary Accession #
Q04671
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UniProt Secondary Accession #
Q15211; Q15212; Q96EN1; Q9UMI5[Other Products]
UniProt Related Accession #
Q04671[Other Products]
Molecular Weight
74,312 Da
NCBI Official Full Name
P protein isoform 1
NCBI Official Synonym Full Names
OCA2 melanosomal transmembrane protein
NCBI Official Symbol
OCA2 [Similar Products]
NCBI Official Synonym Symbols
P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12
[Similar Products]
NCBI Protein Information
P protein
UniProt Protein Name
P protein
UniProt Synonym Protein Names
Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog
UniProt Gene Name
OCA2 [Similar Products]
UniProt Synonym Gene Names
D15S12; P [Similar Products]
NCBI Summary for OCA2
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for OCA2
Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
Research Articles on OCA2
1. Evaluated the association of seven OCA2-HERC2 SNPs and haplotypes with pigmentation characteristics (eye, skin, hair and freckles) in the highly admixed and phenotypically heterogeneous Brazilian population. Such SNPs and haplotypes could be deemed as good predictors for the presence of freckles and for skin, eye and hair pigmentation in the Brazilian population.
Precautions
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Disclaimer
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