OCA2, Polyclonal Antibody

P protein; Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog; OCA2; D15S12; P

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This OCA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the N-terminal region of human OCA2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-OCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes the human homologue of the mouse p
(pink-eyed dilution) gene. The encoded protein is believed to be an
integral membrane protein involved in small molecule transport,
specifically tyrosine - a precursor of melanin. Mutations in this
gene result in type 2 oculocutaneous albinism. [provided by
RefSeq].

Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

OCA2 Antibody (N-Term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the OCA2 antibody detected the OCA2 protein (arrow).

92850

oculocutaneous albinism II

P protein

P protein

D15S12; P  [Similar Products]

P_HUMAN

This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

OCA2: a transporer of tyrosine, a precursor for melanin synthesis, within melanocytes. Regulates the pH of melanosomes and melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the SLC13A transporter family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 15q

Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; melanosome membrane; cytoplasm; integral to membrane; endosome membrane

Molecular Function: protein binding; transporter activity; L-tyrosine transmembrane transporter activity

Biological Process: melanin biosynthetic process; cell proliferation; tyrosine transport; melanocyte differentiation; transmembrane transport; eye pigment biosynthetic process; spermatid development

Disease: Albinism, Oculocutaneous, Type Ii; Skin/hair/eye Pigmentation, Variation In, 1

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Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :

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